一、个人简介
高锦明,男,教授,博士生导师。1986年7月本科毕业于陕西师范大学化学专业,1998年7月硕士毕业于西北农林科技大学植物资源化学专业,2001年8月获中国科学院昆明植物研究所植物化学专业博士学位。现为西北农林科技大学理学院院长、化学与分子工程系教授。2005年6月至2006年6月在加拿大科学院生物技术研究所做访问学者,2007年7月至2008年9月获加拿大国家自然科学基金(NSERC)资助在加拿大科学院生物技术研究所做博士后。
2001年获得中国科学院院长奖学金优秀奖;先后入选教育部“优秀青年教师资助计划”、教育部“新世纪优秀人才支持计划”。2005年获陕西省“优秀博士后”及2009年获陕西省优秀留学回国人员称号,享受国务院政府特殊津贴。
现任西北农林科技大学理学院院长,西北农林科技大学第八、九、十届学位评定委员会第十二分委会主席,西北农林科技大学第三、四届学术委员会委员。兼任中国植物学会植物化学及资源学专业委员会委员、陕西省资源化学与可持续利用工程研究中心主任、陕西省化学会常务理事、陕西省化学会有机化学专业委员会副主任委员, 陕西省药学会药物化学专业委员会副主任委员, 西部植物化学国家工程研究中心首席科学家、陕西省学位委员会第三届学科评议组成员、陕西省陕南中药产业发展专家顾问组成员、国家自然科学基金项目评审专家、教育部科技奖励评审专家。
国际知名杂志 Journal of Medicinal Chemistry, European Journal of Medicinal Chemistry, Journal of Natural Products, Journal of Agricultural and Food Chemistry,Bioorganic & Medicinal Chemistry Letters、Food Chemistry、Journal of Molecular Catalysis B: Enzymatic, Mini-Reviews in Medicinal Chemistry 等10余种杂志的审稿人。
《西北农林科技大学学报(自然科学版)》、《Bioprocess》及《生物质化学工程》编委。
二、科研课题
近年来,先后主持国家自然科学基金、国家林业公益性行业科研专项子课题、“十二五”国家科技支撑计划子课题、教育部博士学科点专项科研基金等国家、省部级科研项目。
三、研究领域
1、中药药效物质基础研究、天然活性成分结构改造与功能研究
2、基于靶蛋白结构的天然产物结构修饰与构效关系
3、新型小分子神经生长因子NGF类化合物发现与药物开发
4、天然产物的生物转化、生物合成与调控
四、开设课程
长期致力于有机化学、植物化学的教学与科研工作,先后承担本科生有机化学、天然药物化学等课程教学,为博、硕士研究生讲授天然产物化学进展、天然产物化学、有机分析、有机合成等课程。
五、主要科研成果与学术论文
近年来,申请国家发明专利26项(授权19项),获省部级奖3项,主编(参编)教材、专著6部。主讲(编)的《植物化学》课程分别获省级、国家级精品课程。在Chem. Rev.、Nat. Prod. Rep.、J. Nat. Prod.、J.Agric. Food Chem.、Org. Biomol. Chem.、Eur. J. Med. Chem.等国内外核心期刊发表论文200余篇,其中SCI收录140篇。所发表论文的H-指数(H-index)为20。
代表性论文:
(1)He Li, Jun-Mian Tian, Hao-Yu Tang, Shi-Yin Pan, An-Ling Zhang*, Jin-Ming Gao* Chaetosemins A-E, new chromones isolated from an Ascomycete Chaetomium seminudum and their biological activities. RSC Advances, 2015, 29185–29192.
(2)Bai, Rui; Zhang, Cheng-Chen; Yin, Xia; Wei, Jing; Gao, Jin-Ming*. Cyathane diterpenoids with neurotrophic activity from cultures of the fungus Cyathus striatus. Journal of Natural Products, 2015, DOI: 10.1021/np501030r
(3)Bai, Meng-Meng#; Shi, Wei#; Tian, Jun-Mian; Lei Ming; Kim, Young Ho; Kim, Jang Hoon*; Sun, Ya Nan; Gao, Jin-Ming*. Soluble epoxide hydrolase inhibitory and anti-inflammatory components from the leaves of Eucommia ulmoides Oliver (Duzhong). Journal of Agricultural and Food Chemistry, 2015,63(8): 2198–2205.
(4)Hao-Yu Tang#, Qiang Zhang#, Yu-Qi Gao, An-Ling Zhang, Jin-Ming Gao*. Miniolins A–C, novel isomeric furanones induced by epigenetic manipulation on Penicillium minioluteum. RSC Advances, 2015, 5 (3), 2185 – 2190.
(5)Zhang, Qiang; Xiao, Jian; Sun, Qing-Qing; Qin, Jian-Chun; Pescitelli, Gennaro; Gao, Jin-Ming*. Characterization of cytochalasins from the endophytic Xylaria sp. and their biological functions.Journal of Agricultural and Food Chemistry, 2014, 62 (45): 10962–10969.
(6)Dong-Mei Wang#, Cheng-Chen Zhang#, Qiang Zhang, Nusrat Shafiq, Gennaro Pescitelli, Deng-Wu Li,Jin-Ming Gao*. Wightianines A–E, dihydro-β-agarofuran sesquiterpenes from Parnassia wightiana, and their antifungal and insecticidal activities. Journal of Agricultural and Food Chemistry, 2014,62 (28): 6669–6676.
(7)Shuai Dong, Jiang-Jiang Tang*, Cheng-Chen Zhang, Jun-Mian Tian, Jun-Tao Guo, Qiang Zhang, He Li,Jin-Ming Gao*. Semisynthesis and in vitro cytotoxic evaluation of new analogues of 1-O-acetylbritannilactone, a sesquiterpene from Inula britannica. European Journal of Medcinal Chemistry2014, 80, 71–82.
(8)Qiang Zhang, Shi-Qiong Wang, Hao-Yu Tang, Xiao-Jun Li, Lu Zhang, Jian Xiao, Yu-Qi Gao, An-Ling Zhang, Jin-Ming Gao*. Potential allelopathic indole diketopiperazines produced by the plant endophytic Aspergillus fumigatus Using the One Strain−Many Compounds Method. Journal of Agricultural and Food Chemistry, 2013, 61(47):11447-11452.
(9)(Cover image) Jin-Ming Gao*, Sheng-Xiang Yang, Jian-Chun Qin. Azaphilonoids: Chemistry and Biology, Chemical Reviews, 2013, 113(7): 4755-4811. (IF = 45.661)
(10) Yu-Bin Bai, An-Ling Zhang, Jiang-Jiang Tang, Jin-Ming Gao*. Synthesis and antifungal activity of 2-chloromethyl-1H-benzimidazole derivatives against phytopathogenic Fungi in vitro.Journal of Agricultural and Food Chemistry, 2013, 61 (11): 2789–2795.
(11) Han-Wei Liu, Xiu-Zhu Yu, Daniele Padula, Gennaro Pescitelli, Zhi-Wei Lin, Fei Wang, Kai Ding, Ming Lei, Jin-Ming Gao*. Lignans from Schisandra sphenathera Rehd. et Wils. and synthetic schisantherin A analogues: absolute configuration, and their estrogenic and anti-proliferative activity. European Journal of Medcinal Chemistry, 2013, 59(1): 265-273.
(12) Sheng-Xiang Yang, Jian Xiao, Hartmut Laatsch, Julian J. Holstein, Birger Dittrich, Qiang Zhang, Jin-Ming Gao*. Fusarimine, a novel polyketide isoquinoline alkaloid, from the endophytic fungus Fusarium sp. LN12, isolated from Melia azedarach. Tetrahedron Letters, 2012, 53(47), 6372–6375.
(13) Xiao-Jun Li, Qiang Zhang, An-Ling Zhang, Jin-Ming Gao*. Metabolites from Aspergillus fumigatus, an endophytic fungus associated with Melia azedarach, and their antifungal, antifeedant, and toxic activities. Journal of Agricultural and Food Chemistry, 2012, 60 (13): 3424–3431.
(14) Sheng-Xiang Yang, Hong-Peng Wang, Jin-Ming Gao*, Qiang Zhang, Hartmut Laatsch*, and Yi Kuang. Fusaroside, a uinque glycolipid isolated from Fusarium sp., an endophytic fungus in Melia azedarach. Organic & Biomolecular Chemistry, 2012, 10(4): 819-824.
(15) Guang-Wei Wu, Jin-Ming Gao*, Xin-Wei Shi, Qiang Zhang, Shao-Peng Wei, Kan Ding.Microbial transformations of diosgenin with the white-rot basidiomycete Coriolus versicolor. Journal of Natural Products, 2011, 74(10): 2095–2101.
(16) Xin-Wei Shi, Li Liu, Jin-Ming Gao*, An-Ling Zhang. Cyathane diterpenes from Chinese mushroom Sarcodon scabrosus and their neurite outgrowth-promoting activity. European Journal of Medcinal Chemistry, 2011, 46(7): 3112-3117.
(17) Jin-Ming Gao*, Jin-Chun Qin, Gennaro Pescitelli, Sebastiano Di Pietro, Ya-Tuan Ma, An-Ling Zhang. Structure and absolute configuration of novel polyketide pigments from the fruiting bodies of the fungus Cortinarius rufo-olivaceus. Organic & Biomolecular Chemistry, 2010, 8(15): 3543–3551.
(18) Jin-Ming Gao, Pierre Kamnaing, Taira Kiyota, Jean Watchueng, Takahiro Kubo, Suwatchai Jarussophon, Yasuo Konishi, One-step purification of palmatine and its derivative dl-tetrahydropalmatine from Enantia chlorantha using high-performance displacement chromatography,Journal of Chromatography A, 2008, 1208 (1-2): 47-53.
(19) Jin-Ming Gao*, Wen-Jun Wu, Ji-Wen Zhang, Yasuo Konishi, The dihydro-b-agarofuran sesquiterpenoids, Natural Product Reports, 2007, 24(5): 1153–1189. (IF = 10.715)
六、联系方式
通讯地址:陕西杨凌邰城路3号北校区 西北农林科技大学理学院
邮编:712100
电话:029-87092515;